According to the results of the initial stage of a new study, some forms of male infertility can appear to be treated with the protein which is absent in these forms.During fertilization, the sperm must pass this vital protein - known as protein PLC-zeta (PLCz) - the egg to start the process necessary for the development of the embryo.In laboratory studies, the scientists managed to produce active human protein PLCz.They found that adding PLCz to sperm with a defective protein fertilization has made possible.
According to scientists, this procedure can significantly increase the chance of a successful pregnancy."We know that some men are infertile because their sperm activates the oocyte.Even if the sperm enters the egg, nothing happens.In such semen may not correctly functioning version of the protein PLCz, which is the main element initiating the next stage of pregnancy, "- said on behalf of the co-director of research Tony Lai, professor of the Institute of Molecular and Experimental Medicine at the
«However, if the unfertilized egg to implement the active human protein PLCz, it responds exactly as it should react at fertilization, resulting in the successful development of the embryo to the blastocyst stage, which plays a vital role in the successful development of pregnancy" - saysBarking.Lai recognizes that the application of researchers has been limited to laboratory experiments, and they can not be used in the same manner in clinics for the treatment of infertility.Nevertheless, the findings, he said, could lead to new ways to treat men with certain forms of infertility.
«In the future, we could produce a human protein PLCz and use it to stimulate egg activation in a natural way", - concludes Lai."Among couples undergoing IVF, is, ultimately, would increase the chances of having a baby, and successful treatment of infertility."
study was published Sept. 21 in the online issue of the journal Fertility and Sterility.