A new study suggests that the discovery of two inherited genetic variation may help doctors identify men at increased risk of aggressive prostate cancer.According to researchers from the Medical College of Cornell's Vale, the risk of the disease can increase in three or even four times, depending on what kind of a man is present variation."Previously, we thought that only genes that produce proteins that are responsible for the development of the disease.However, this study shows that in the non-coding regions of the genome lies the hereditary information that is likely to play a significant role in the development of cancer, "- said in a press release from the college on behalf of one of the authors of the study Dr. Mark Rubin, professor of oncology and pathology.
most serious risk factor for prostate cancer is the presence of this disease in family history.Therefore, researchers have tried to identify DNA regions that either the deleted or duplicated genetic information in men with prostate cancer com
study, which was published on April 9 in the journal Proceedings of National Academy of Sciences, found that these so-called copy number variations (Cheka) play a significant role in the development of prostate cancer.The researchers found two differences in the number of copies between the genomes of men with aggressive prostate cancer and men without the disease.They were also able to duplicate the results in a group of 800 patients from the United States."Research has shown that the variation number of copies are set in relation to the development of cancer," - adds one of the leading authors of the study, Dr. Francesca Demichelis, who is a senior lecturer at the Center for Integrative Biology at the University of Trento in Italy, as well as an associate professor at the Institute for Computational BiomedicineMedical College of Cornell University Vale.
During laboratory testing the effect of these two genetic variations, researchers have demonstrated that variations promote penetration and growth of cancer cells, thereby increasing the risk of prostate cancer in some men in four times.The total population of these variations are inherited only about 3% of men.Among men with aggressive prostate cancer, the figure is much higher, as the authors emphasize.
However, researchers note that these variations are not the only cause of aggressive prostate cancer, and that they are likely to assist other risk factors that may lead to the development of prostate cancer.As the researchers say, they are now trying to find other variations that could help them to develop a comprehensive DNA test to identify men at risk of developing aggressive prostate cancer."With this new research, we begin to understand that the differences associated with inherited genetic variations explain not only why we have different look or react to the use of drugs, but also why we are developing certain diseases"- says Rubin."This is the first study to suggest that these variations may explain the tendency to cancer.This new line of research will also allow us to study the biology of the start of prostate cancer. "