according to a new European study, a new drug that helps to reduce uterine fibroids and helps control caused her heavily leaking with heavy menstrual bleeding.In one study it proved the effectiveness of ulipristal acetate, which is more effective than placebo reduces benign tumors of the uterus.In another study, the drug ulipristal acetate compared with the action of another drug, Lupron, which also helps to reduce bleeding during uterine cancer.
Both studies were published in the issue of the "New England Journal of Medicine» (The New England Journal of Medicine) of 2 February.
ulipristal acetate is a chemical substance used in the preparation of emergency contraception, distributed under the brand name Ella.However, during the study dosage taken by women with uterine cancer were lower than in the preparation.If the clinical trials have confirmed the efficacy, the two companies «Watson Pharmaceuticals Inc.» in New Jersey and «PregLem» Switzerland will spread ulipristal acetate as a remedy for uterine
One out of four women have symptoms of uterine
Uterine cancer is the most common indication for operations hysterectomy.Held annually about 600 000 operations.About 1 in 4 women of childbearing age have uterine fibroids symptoms, such as painful and heavy menstruation, associated with iron deficiency, abdominal pain, the inability to become pregnant.This figure is given by the National Institutes of Health.
«Surgery - the most common way of getting rid of uterine fibroids, but many women prefer non-surgical methods," - says Jacques Donnez researcher, Master of Medical Sciences of the Catholic University of St. Luke in Brussels, Belgium.Lupron alleviates the symptoms of, reducing the fibroids, but does not eliminate them completely.The drug works by blocking the production of estrogen - a hormone that contributes to fibroids.Many women who take this medication, there are hot flashes and menopausal symptoms.
In a recent study, experts found that women with bleeding caused by uterine fibroids receiving ulipristal acetate for three months, observed the same positive developments, as well as in women receiving injections of Lupron.But the first group of women had fewer side effects.
drug reduces bleeding and reduces swelling
moderate to severe hot flashes were detected in about 10% of women who took ulipristal acetate, and 40% of women receiving Lupron.In another study, ulipristal acetate equated with a placebo effect in patients with bleeding and anemia.Drug treatment for 13 weeks helped to control uterine bleeding in 90% of patients.
In both studies, tumor shrinkage was observed during treatment and for some time later."That surprised us, - says Donnez.- We know that once patients stop taking leuprolide acetate, the symptoms quickly return.However, in the case of ulipristal acetate picture is quite different. "
«New drug may help patients avoid surgery.This means that women are not required to take the drug consistently enough to take it when symptoms return, "- he says.
number of hysterectomies are still great
Elizabeth Stuart, Master of Medicine, professor of obstetrics and gynecology at the Mayo Clinic in Rochester, Minnesota, said that while it is not necessary to make findings as safe short-term repeated treatment with this drug.If it is safe, the drug, specifically, has the potential to become a disposal of the surgical procedure.
She also notes that there are sufficient alternatives to surgery, but many women do not know about them."Patients with uterine fibroids need to have full information about all kinds of treatment options - she says.- This does not mean that the right level of awareness all the women refuse to hysterectomy, but many probably will choose medical treatment. "