Different people react to smoking marijuana differently - in some there is paranoia and anxiety, others vice versa feel relief.Now, unique research on brain scans suggested that such reactions may occur due to the two ingredients in the composition of marijuana, which may act independently of each other.British scientists, who observed the impact of these two ingredients - Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) - the brain 15 young people say that this study shows how the drug can either soothe the mind of man, or lead to the excitement.
«There are absolutely opposite opinions about marijuana," - said study lead author Dr. Sagnik Bhattacharya, who is a researcher of the study of psychoses in the Institute of Psychiatry, Kings College, London."Some consider it to substantially secure and in some cases it may be useful as a treatment.Other associate marijuana with potentially grave consequences for public health in relation to mental health.This study explains why the truth is somewhere in be
The results of this study were published in the January issue of the journal "Archives of General Psychiatry."According to members of the research team Bhattacharya, that marijuana causes psychotic symptoms such as paranoid and / or delusional thinking in completely healthy people, it was noted long ago."Some studies have clearly shown that regular use of marijuana (or cannabis) sensitive people associated with an increased risk of psychiatric disorders such as schizophrenia, in which lost touch with reality," - says Bhattacharya.
However, the question of what processes in the brain lead to this, there is still no reply was received.To conduct the study, researchers used obtained by MRI images of the brain of 15 healthy young men who were described as "occasional use marijuana."Age of the subjects averaged 27 years.During the three tests carried out using an MRI scanner, the young people received one of three identical-looking capsules: the first contained 10 milligrams of THC (which is considered to be a moderate dose), the second - 600 milligrams of CBD, and the third was filled with flour.
Testing was conducted under strict control and supervision, and does not include the actual smoking marijuana.MRI scanning, which allows you to track brain activity in real time, went from one to two hours after ingestion of capsules.During the scan, the subjects had to perform simple tasks in the visual perception (eg, press the button to display the direction of a series of flashing arrows).Psychiatric evaluation was carried out during the imaging of the brain.The research team found that THC and CBD affect the brain, appear to be completely different.
THC caused a custom activity in two areas of the brain (striatum and lateral prefrontal cortex) that are key to people's perceptions of reality.THC, apparently increased the brain responses to stimuli, which are insignificant in other conditions, reducing at the same time response that is usually significant and important.In other words, under the influence of THC healthy people can give much more importance to detail the reality around them, than they would have done it without the effects of chemicals on the brain.
also called THC, according to the authors, a significant increase in paranoid and delusional thinking, and the more unbalanced were 'normal' brain responses, the more serious - or even paranoid psychotic reaction.However, the impact of the second main component of marijuana, CBD, it was just the opposite.According to the research team, receiving capsules CBD caused, apparently, the activity of the brain, associated with an adequate response to the essential stimuli of reality.According to Bhattacharya, it suggests that, ultimately, marijuana may play both positive and negative role in the context of psychosis.Also, as a result of research, it can be assumed that perhaps "probability of use as a method of treating psychosis, at least CBD still exists, despite the fact that another ingredient in marijuana, THC, increases the risk of psychoticcomplications ", - he said.
Dr. Joseph Coyle, a professor of psychiatry and neurology at Harvard Medical School in Boston, said that this study helps to dot the «i» with respect to understanding the perception of reality associated with marijuana."This refers to a particular perception, in this case caused by marijuana, in which a person thinks that other people who, for example, just talking on the subway, are talking about it, or that people take my hat off just doing it becauseit "- he said."So I think this study is very important because it examines the types of high anxiety and hypervigilance, which are major factors in psychosis, and shows what happens in the brains of people experiencing these feelings.So I think that this study is one more element of the foundation of understanding of the direct causal link."It is a link, connecting psychological condition experienced by people under the influence of marijuana, and psychophysical response of the brain.And it's very interesting. "