international group of scientists at the University of California, Davis, the absence of the protein that covers the sperm, explains why a large number of cases of male infertility worldwide.Description The discovery was published in the journal Science Translational Medicine.The research may shed light on the development of treatments for infertility.Beta-defensin protein encoded by the gene DEFB126 126, which helps sperm to penetrate the shell of mucus and avoid exposure of female immune system, thereby allowing them to reach the oocyte.
study semen samples from the US, UK and China has shown that about a quarter of men around the world have two copies of the defective gene (which may significantly affect their fertility).By studying 500 couples from China, researchers found that couples with beta-defensin 126 less able to conceive than other couples (a difference of 30%).The same year, the first two couples are less able to bear a child.
«Infertility affects 10 to 15 percent of
«Some researchers believe that the past decade of declining male fertility in the world for unknown reasons.This downward trend can reveal problems with the defective gene DEFB126 », - says Dr. Gould.Cherry said that they hope to follow-up on the program of the United States for the treatment of infertility for further study of the role of the mutation.
Science Translational Medicine