A recent study Karolinska Institutet has added new knowledge about the mechanism of chromosomal replication - one of the most fundamental processes.In the long term, the results may lead to new ways to treat cancer.The report of this study, published in the prestigious scientific journal «Nature» (Nature).During studying DNA replication in yeast cells, researchers at Karolinska Institutet found that a protein complex (Smc5 / 6) helps to release torsional stress created in the DNA during replication in preparation for cell division.
«The results of our study indicate that the tension in the DNA may be freely distributed over the length of the chromosome than previously" - said Professor Camille Sёrgen Institute, the head of a group of scientists who conducted the study. "
Thus, the study sheds more light on the mechanism behind the most fundamental processes of life.Since topoisomerase enzymes known ability to relieve stress caused by DNA replication are common targets for the treatment of cancer, the d
when a fertilized egg develops into a complete organism, or when old cells are replaced by new, all these processes take place through cell division.Since it is necessary that the daughter cells developed normally and survived, each of them should get a full set of 46 chromosomes, consisting of two-tape DNA helices.Since the original parent cell came into existence in the form of cells with 46 chromosomes Tew, they must be duplicated before division takes place.
During this process, the DNA double helix is separated in order to provide access to the replication apparatus of each DNA strand.Such tearing strands creates stress in the form of overly twisted DNA in the vicinity of the zone replication.If the voltage is removed, replication can be slowed down or even to stop, and this in turn can lead to mutagenesis and / or cell death.
«Several modern cancer treatment therapies directed to topoisomerase, but there is a problem in that some cancers become resistant to these therapies," - says Professor Sёrgen."Due to the fact that we were able to detect that Smc5 / 6 complex releases tension that is generated during the replication process, our results may give rise to a drug aimed at Smc5 / 6.Thus, there may be another tool for inhibiting the growth of tumors. "
Sёrgen Camilla is a member of the Royal Swedish Academy of Sciences, which is supported by the Knut and Alice Foundation Wallenberg.This work was also supported by the European Research Council (Grant ERC), the Swedish Research Council (VR), the Swedish Cancer Society, Vinnova, the Swedish Foundation for Strategic Research (SSF), the Japan Science and Technology Agency, the Ministry of Education, Culture, Sports, Science andTechnology, Japan Society for the development of science and research funds Cornell and Karolinska Institutet.