The researchers say they were able to identify one of the main reasons why women who inherit a mutated gene BRCA1, in the long term have a higher risk of breast cancer.This discovery could help in the search for new treatments.The second gene, called PTEN, - in this case plays a key role, scientists said in a study published on Sunday.
experts have long known that BRCA1 normally responsible for "repairing" other damaged genes.Therefore, if it is subjected to a mutation that unrepaired defect can lead to the development of cancer.But the specifics of this process has long been unclear.
new research "rests" in the PTEN, which normally acts as a brake on the development of cancer.Researchers have found evidence that breast cancer is associated with a mutation of BRCA1, because often "broken" the PTEN gene is not receiving the necessary repairs.This leads to a whole cascade of chemical reactions which result becomes the occurrence of cancer.
BRCA1 defects can lead to breast cancer, said Dr. Ramon Parsons
PTEN was discovered about 10 years ago, and scientists know a lot about it and the chemical reactions that are triggered into action when PTEN is not working.Pharmaceutical companies conduct animal experiments, trying to find a cure for cancer by interrupting the cascade of chemical reactions, and they have already received a number of encouraging results.
Breast cancer associated with a mutation of the gene BRCA1, usually occurs in the form of aggressive and poorly predicted.BRCA1 and its cousin BRCA2 are responsible for less than 15 percent of all breast cancers.