existence in each organ the stem cells responsible for regeneration of its component tissues, is well documented.But how wide is the range of possibilities of their differentiation, and whether they can take part in the regeneration of other organs, remains unclear.
this question sheds light study of a group of Japanese scientists from the University of Hiroshima.They studied the possibility of participation in the restoration of liver cells from the tissue of the heart, brain, skin and kidneys.
work was carried out on rats.For toxic liver damage were used carbon tetrachloride;day after injection into the peritoneal cavity of rats transplanted substance in liver slices of donor tissue.Rat donors were labeled with the green fluorescent protein gene;In addition, males from females transplanted tissue and vice versa.Thus, the donor cells and their progeny carry two genetic tags that allow them to detect cells of the recipient - the presence / absence of the Y chromosome, and green fluorescent protein.
week after transplantation into the liver of rats-recipients were detected with cells of donor origin hepatocyte phenotype.After two and four weeks scope of these cells is significantly increased.
results of this study indicate the ability of stem cells from the tissue of the heart, kidney, skin and brain differentiate into hepatocytes when transplanted into a damaged liver.Hence these cells are more capable of differentiation than the cells only relevant body tissue.
Materials research presented in the article Watanabe H, et al.Differentiation of a hepatic phenotype after heterotropic transplantation of heart, kidney, brain, and skin tissues into liver in F344 rats.Biochem Biophys Res Commun.2007 Mar 23; 354 (4): 841-5.