Scientists from the University of Madison (Wisconsin, USA) found that epigallocatechin-3-gallate (EGCG), a component of green tea together with small doses of celecoxib (a drug from the group of inhibitors of cyclooxygenase-2) slow the progression of prostate cancer.Experiments were performed in cell culture and in mice (a model for prostate cancer).
«Celecoxib and green tea act synergistically, ie their combined effect is stronger than the effect of each substance individually.We hope that the findings will lead to the creation of simple methods of prevention and treatment of cancer, "- said Hasan Mukhtar, one of the authors.
It was already known that the enzyme cyclooxygenase-2 (COX-2) associated with different types of cancer, including prostate cancer.Mukhtar and his colleagues in mice have demonstrated that COX-2 inhibitors suppress the growth of prostate cancer.However, it is known that high doses of COX-2 inhibitors may cause adverse effects to the cardiovascular system.
In 2004, the same group
«We hypothesized that COX-2 inhibitors may work in combination with other substances.In combination with EGCG COX-2 inhibitor can be used in a small safe dose "- say the authors of the work.
In the latest study, researchers used celecoxib and polyphenol from green tea in liquid form.The idea was that, in real life, people find it easier to drink green tea, and do not take Supplements.The combination of COX-2 inhibitor and EGCG resulted in growth inhibition of cancer cells to additional 15-28 percent as compared with the use of only one substance.
«Prostate cancer arises because of several defects in the cellular mechanisms, a combination therapy therefore justified.If clinical trials involving humans will be able to get similar results, we can talk about simple and inexpensive method of treatment "- concludes Mukhtar.